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INGREDIENT RESEARCH · FORMULA DESIGN

The Science Behind the NovaStemix® Formula

NovaStemix® combines 12 selected ingredients in a daily serving of four capsules. Ingredient selection draws on laboratory research and, for some ingredients, human studies, with a focus on NAD⁺ metabolism, mitochondrial function, cellular maintenance and stress responses.

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We consider ingredient characteristics, raw material specifications and daily amounts as part of the overall design. Explore each ingredient’s source, research background and reason for inclusion to understand the formula and make an informed choice.

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The Logic Behind Our Formula

Cells need energy to function, systems to recycle damaged components, and ways to respond to oxidative stress and inflammatory signals. These processes are closely connected: energy supports cellular maintenance, while maintenance and protective responses help preserve the normal function of mitochondria and other cellular structures.

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NovaStemix® is formulated with these connections in mind. NR is a precursor of NAD⁺, while coenzyme Q10 participates in mitochondrial electron transport. Spermidine research focuses on autophagy and cellular maintenance; studies of curcumin and other plant polyphenols examine stress responses and inflammatory signalling. We consider ingredient characteristics, raw material specifications and daily amounts to bring these complementary areas of research into a practical daily formula.

Four Biological Focus Areas

The NovaStemix® formula draws on research into four interconnected biological areas: how cells respond to stress, produce energy, recycle damaged components and regulate inflammatory signals.

Cellular Stress Responses

Cells use systems such as Nrf2 to respond to oxidative stress and maintain internal balance. Studies of sulforaphane and curcumin examine these internal defence mechanisms.

Mitochondrial Function

Mitochondria play a central role in cellular energy production. NR is a precursor of NAD⁺, while coenzyme Q10 participates in mitochondrial electron transport. The two ingredients relate to different aspects of energy metabolism.

Autophagy & Maintenance

Autophagy breaks down and recycles damaged or unneeded cellular components. Cell and animal studies show that spermidine can promote this process, providing a mechanistic basis for the formula’s focus on cellular maintenance.

Inflammatory Signalling

Inflammatory signals are part of the body’s normal defence. Persistent low-grade inflammation is associated with ageing. Research on curcumin and resveratrol examines the regulation of pathways such as NF-κB.

Explore the 12 Ingredients

Explore the sources, biological properties and research background of the 12 ingredients in NovaStemix® to understand the reasoning behind their selection.

PLANT POLYPHENOL · STRESS & METABOLISM

Resveratrol

Resveratrol is a plant polyphenol studied for its effects on cellular stress responses, mitochondrial function and energy metabolism. Research in these areas, including human intervention studies, informs its selection for NovaStemix®.

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NAD⁺ PRECURSOR · ENERGY METABOLISM

Nicotinamide Riboside

NR is a precursor of NAD⁺, which participates in energy metabolism and cellular regulation. Human randomised controlled trials have observed increases in blood NAD⁺ levels following NR supplementation, informing its selection for the formula.

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PLANT FLAVONOID · INFLAMMATORY SIGNALLING

Quercetin

Quercetin is a plant flavonoid found in foods such as onions and apples. Cell studies have observed modulation of NF-κB and MAPK signalling, providing a mechanistic rationale for its inclusion in the formula.

Nrf2 SIGNALLING · CELLULAR DEFENCE

Sulforaphane

Sulforaphane is a compound derived from cruciferous vegetables that activates Nrf2 signalling. A human study using a broccoli sprout preparation containing sulforaphane observed increased expression of genes encoding protective enzymes in upper airway cells.

AUTOPHAGY · CELLULAR MAINTENANCE

Spermidine

Spermidine is a polyamine found naturally in human cells and many foods. Cell and animal studies show that it can promote autophagy, helping cells break down and recycle damaged components. These findings inform its selection for NovaStemix®.

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MITOCHONDRIAL FUNCTION · REDOX ACTIVITY

PQQ

PQQ (pyrroloquinoline quinone) is a compound with redox activity. Cell studies have shown that it can promote mitochondrial biogenesis through mechanisms involving PGC-1α, providing a mechanistic rationale for its inclusion in the formula.

CAROTENOID · LIPID PROTECTION

Astaxanthin

Astaxanthin is a fat-soluble carotenoid studied for its antioxidant activity in lipid environments. A randomised controlled trial in middle-aged and older adults observed lower levels of lipid oxidation markers in red blood cells.

MITOCHONDRIAL ENERGY · ANTIOXIDANT ACTIVITY

Coenzyme Q10

Coenzyme Q10 is a fat-soluble compound naturally present in the body. It participates in mitochondrial electron transport, while its reduced form acts as an antioxidant. These biological roles inform its inclusion in NovaStemix®.

GINSENOSIDES · STRESS RESPONSES

Ginseng Extract

Ginseng extract contains ginsenosides and other bioactive constituents. Human research using specific ginseng preparations has examined fatigue and oxidative stress markers. This research informs its selection for NovaStemix®.

PLANT POLYPHENOL · INFLAMMATORY SIGNALLING

Curcumin

Curcumin is a polyphenol found in turmeric. Experimental studies have observed effects on NF-κB and Nrf2 signalling, while human intervention studies have assessed inflammatory markers. This research informs its selection for NovaStemix®.

EGCG · CELLULAR DEFENCE

Green Tea Extract

Green tea extract contains catechin polyphenols, including EGCG. Cell studies have observed effects of EGCG on oxidative stress responses and inflammatory signalling, including NF-κB. These findings inform its inclusion in the formula.

PIGMENT PROTEIN · CELLULAR DEFENCE

Phycocyanin

Phycocyanin is a pigment protein found in spirulina and other cyanobacteria. Laboratory and animal studies have observed antioxidant activity and effects on inflammatory responses, providing a mechanistic rationale for its selection in NovaStemix®.

Learn More About NovaStemix®

Explore the NovaStemix® formula, recommended daily intake and guidance for use to make an informed choice about your daily supplementation.

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