What Is Sulforaphane?
Sulforaphane is a plant compound in the isothiocyanate family. It forms when glucoraphanin, found in broccoli and other cruciferous vegetables, is broken down by the enzyme myrosinase.
Researchers study how sulforaphane influences the Keap1–Nrf2 pathway, a system that regulates genes involved in cellular defence and responses to oxidative stress.
NovaStemix® uses broccoli-derived glucoraphanin, the precursor to sulforaphane. The amount converted to sulforaphane can vary with enzyme activity and gut microbial metabolism.
Natural Source & Ingredient Form
Broccoli seeds and young sprouts naturally contain glucoraphanin, the precursor to sulforaphane. Research has examined preparations made from both as sources of this compound.
NovaStemix® uses a broccoli-derived ingredient specified by its glucoraphanin content. We consider its form, specification and daily amount alongside the other ingredients within the complete 12-ingredient formula.
Scientific Context
Nrf2 Signalling
Human Research
Formulation Context
Experimental studies examine how sulforaphane influences Nrf2-regulated genes involved in glutathione production and cellular defence. These findings inform research on cellular responses to oxidative stress.
A human study using a broccoli sprout preparation observed increased expression of selected Phase II enzyme genes in nasal cells. These enzymes are involved in cellular defence and the processing of reactive compounds.
Ingredient form, myrosinase activity and dose can affect sulforaphane exposure. These details guide how we interpret research findings in relation to the glucoraphanin ingredient used in NovaStemix®.
Why It Is Included in NovaStemix®
NovaStemix® includes broccoli-derived glucoraphanin as a precursor to sulforaphane. Research on sulforaphane examines Nrf2 signalling and genes involved in glutathione production, cellular defence and responses to oxidative stress.
This research brings an emphasis on the cell’s own defence systems alongside the metabolic signalling studied with resveratrol and the inflammatory signalling examined with quercetin and curcumin.
These complementary research areas inform our formulation approach. Each ingredient is considered in terms of its form, specification and daily amount within the complete 12-ingredient formula.
Research Areas
Selected areas of experimental sulforaphane research that inform our ingredient selection for NovaStemix®.
EXPERIMENTAL RESEARCH
Nrf2 Signalling
EXPERIMENTAL RESEARCH
Inflammatory Signalling
EXPERIMENTAL RESEARCH
Glutathione Metabolism
EXPERIMENTAL RESEARCH
Autophagy
Related Ingredients
RESVERATROL
QUERCETIN
CURCUMIN
Resveratrol is studied for its effects on metabolic signalling and mitochondrial function in experimental models. These research areas inform its inclusion within the complete NovaStemix® formula.
Quercetin research examines oxidative stress responses and inflammatory signalling, including NF-κB and MAPK, in cell models. These areas inform its selection as part of the NovaStemix® formula.
Curcumin is studied for its effects on NF-κB and related inflammatory signalling in cell models. This research informs its inclusion alongside other plant compounds in the NovaStemix® formula.