What Is Nicotinamide Riboside (NR)?
NR is a member of the vitamin B3 family that the body can convert into NAD⁺ (nicotinamide adenine dinucleotide).
NAD⁺ helps transfer electrons during reactions that convert nutrients into usable energy. It is also used by sirtuins and other enzymes involved in cellular regulation and maintenance.
These roles explain why NR is studied in relation to energy metabolism, cellular maintenance and healthy ageing.
Natural Occurrence & Ingredient Form
NR occurs naturally in small amounts in foods such as cow’s milk, where it is present alongside other vitamin B3 compounds.
NovaStemix® uses nicotinamide riboside chloride (NRCl), a defined salt form of NR. We consider the ingredient’s identity, specification and daily amount as part of the complete formulation design.
The Research Basis
NAD⁺ in Human Studies
Cellular Mechanisms
Formulation Context
Human trials have observed increases in blood NAD⁺ and related metabolites after NR supplementation. These findings support its investigation as an oral NAD⁺ precursor.
Cell and animal studies investigate links between NR, NAD⁺ availability, sirtuin activity and mitochondrial metabolism. These findings provide mechanistic context for its study in healthy ageing.
These research findings inform NR’s selection for NovaStemix®. Its role as an NAD⁺ precursor is considered alongside the other ingredients within the formula’s focus on cellular energy and maintenance.
Its Role Within Our Formulation
NR is included in NovaStemix® as a precursor to NAD⁺, a coenzyme involved in energy metabolism and used by enzymes that regulate cellular processes.
We consider this role alongside coenzyme Q10, which participates in mitochondrial electron transport, and plant polyphenols studied for cellular signalling. These different biological characteristics guide the formula’s complementary design.
NAD⁺ Biosynthesis
NR provides a precursor that the body can use to produce NAD⁺.
Pathway Analysis
NR’s precursor role and the biological functions of NAD⁺ in cellular energy and maintenance.