What Is Spermidine?
Spermidine is a naturally occurring polyamine found in human cells and in foods such as wheat germ.
Experimental studies investigate its effects on autophagy, the process by which cells break down and recycle their components. One mechanism studied involves inhibition of EP300, an enzyme involved in protein acetylation.
These findings explain the interest in spermidine within healthy ageing research and inform its selection for the NovaStemix® formula.
Natural Source & Ingredient Form
Wheat germ is a natural source of spermidine and other polyamines. The composition of an extracted ingredient is assessed through its specification and analysis.
NovaStemix® uses a wheat-germ-derived polyamine preparation. We consider the ingredient’s form, specification and daily amount within the complete 12-ingredient formula.
The Science Behind
Autophagy Research
Human Research
Formulation Context
Experimental studies investigate how spermidine influences autophagy, including mechanisms involving EP300 inhibition and protein acetylation. These findings provide a mechanistic basis for research into cellular recycling and maintenance.
A 12-month randomised trial in 100 older adults with subjective cognitive decline tested a wheat germ extract providing 0.9 mg spermidine daily. The primary memory outcome showed no significant benefit over placebo.
Preparation, dose, duration and study population matter when interpreting findings. We assess these details alongside ingredient identity and specification when considering research within the complete NovaStemix® formula.
Why It Is Included in NovaStemix®
Research into spermidine and autophagy informs our inclusion of a wheat-germ-derived polyamine ingredient in NovaStemix®. Experimental studies examine mechanisms involving EP300 inhibition and protein acetylation.
NR is an NAD⁺ precursor, while resveratrol is studied for its effects on metabolic signalling. We consider these research areas alongside cellular recycling when selecting ingredients for the complete formula.
We consider the polyamine ingredient’s form, composition and daily amount alongside the other components of the 12-ingredient formula.
Research Areas
Selected areas of experimental spermidine research that inform our formulation approach.
EXPERIMENTAL RESEARCH
Autophagy
EXPERIMENTAL RESEARCH
Protein Acetylation
EXPERIMENTAL RESEARCH
Mitochondrial Function
EXPERIMENTAL RESEARCH